|The Statin drugs which lower cholesterol, among
the most prescribed medications currently, (Lipitor, Zocor, Prevastatin et
al) caused cancer in the rat studies EVEN WHEN GIVEN IN THE SAME DOSAGE AS
USUALLY PRESCRIBED TO HUMANS.
In an excellent and highly
informative review article published in 2009, Wainwright et al. 
developed a strong argument that Statin drugs, by depleting cholesterol,
lead to a destabilization of cell membranes "from head to toe." This
problem, in turn, increases risk to a long list of serious health conditions
and diseases, including diabetes, multiple sclerosis, cognitive problems,
hemorrhagic stroke, cancer, and even ALS (amyotrophic lateral sclerosis,
also known commonly as Lou Gehrig's disease). Their arguments are backed up
by references to 85 peer-reviewed journal publications.
These medications are hard on the liver, undermining liver cells for their
action. They also can cause muscle weakness and other side effects.
Statins have also been shown to reduce the relative
risk of heart attacks in men in their 50's by as much as 30%, but, because
heart attacks are relatively rare for this segment of the population,
the absolute risk reduction is only on the order of 2%, a point
that is often missed by the person being treated. (ibid)
Several studies have suggested no link between cholesterol levels and heart attacks
i.e. many who have heart attacks, HAVE NORMAL CHOLESTEROL LEVELS.
(The disclaimer for the Lipitor TV commercial states that Lipitor has NOT
been proven effective at preventing heart attack.)
Also what we've
heard i.e. that Statin drugs prevent heart attacks by reducing
"inflammation" (one theory is that heart attacks are partially caused by
inflammation) has been debunked by several studies including the MS studies on two of the
- they found that while the Statin drugs suppressed the immune system, they
also suppressed proteins that protect people against inflammation and
autoimmune attacks specifically the protein "interleukin-10" (International
detailed profiles on what drugs doctors are prescribing and
sometimes have been known to reward them for prescribing certain medications.
British medical providers are apparently less prone to prescribe Statin
drugs to those who have not had heart attacks. To overcome this, some
of the pharmaceutical companies will begin to offer Statin drugs "over the
counter" hoping to get more customers from the healthy population.
There are many studies on the cholesterol
lowering medications: See
Stopped Our Statins website - very
CoEnzyme Q10 suppressed by statin drugs
Coenzyme Q10 is found naturally in the body. Lower blood levels of this
coenzyme have been found in individuals with certain types of cancer.
Coenzyme Q10 was first identified in 1957. Its chemical structure was
determined in 1958. Interest in coenzyme Q10 as a potential treatment for
cancer began in 1961, when a deficiency of the enzyme was noted in the blood
of cancer patients. Low blood levels of coenzyme Q10 have been found in
patients with myeloma, lymphoma, and cancers of the breast, lung, prostate,
pancreas, colon, kidney, and head and neck.
While coenzyme Q10 may show indirect anticancer activity through its
effect(s) on the immune system, there is evidence to suggest that analogs of
this compound can suppress cancer growth directly. Analogs of coenzyme Q10
have been shown to inhibit the proliferation of cancer cells in vitro and
the growth of cancer cells transplanted into rats and mice.
Certain lipid-lowering drugs, such as the "statins" (Lovastatin,
Pravastatin, and Simvastatin) and Gemfibrozil, as well as oral agents that
lower blood sugar, such as glyburide and tolazamide), cause a decrease in
serum levels of coenzyme Q10 and reduce the effects of coenzyme Q10
The lowered levels of Coenzyme Q10 may be a major factor in the Statins
being a contributing factor to cancers.
Higher Risk of Brain Bleed
Lipitor has been observed to raise the risk for brain bleeds (hemorrhagic stroke) - There is a 20% survival rate
from this type of brain bleed. Even if the risk is small, taking this risk may be like playing Russian Roulette.
Statin induced Cardiomypathy
"I see 2-3 cases of Statin induced cardiomyopathy a week" states the
cardiologist whose paper is up on the FDA website. Dr Langsjoen feels
this is due to a shortage in CoEnzyme Q10 which is caused by the statin
drugs. As he explains there is a slight advantage to these drugs in
heart patients as they have some anti-inflammatory effects but the side
effects far outweigh the slight advantage. (4)
Zocor tested as immuno-suppressant by the MS Society (2003-2011)
"Oral drugs used to lower cholesterol, called statins, were shown in test
tubes to INHIBIT IMMUNE RESPONSES of cells taken from individuals with MS.
This study was previously reported by Dr Oliver Newhaus (Karl-Franzens-University
at Graz, Austria) and colleagues at the April 2002 meeting of the American
academy of Neurology, and now has been published in the October 8, 2002
issue of Neurology."
"Although Statins were shown capable of INHIBITING SEVERAL DIFFERENT IMMUNE
RESPONSES and markers of inflammations typically involved in MS, THEY ALSO
STIMULATED THE RELEASE OF SOME PROTEINS KNOWN TO **INCREASE** inflammation."
"Clinical trials will be necessary to determine whether statin drugs may
benefit individuals with MS. There is already one small-scale trial of ZOCOR
under way in 32 people who have relapsing-remitting MS. This trial is taking
place at the Medical University of South Carolina (Charleston), in Yale
University (New Haven, CT) and at the U of Colorado Health Sciences Center
(Denver). Other studies are under consideration at this time."
Source: "MS Connection", Fall 2002
By 2011, several studies had been done on Zocor with some positive results
as a result of suppressing the immune system (with Zocor) (5)
Higher incidence of cancer in those taking statin drugs (2-2003)
A trial which randomized over 5000 at risk elderly patients over a 3 year
period (double blind, placebo controlled) showed a 25 percent greater
incidence of cancer in those patients taking Pravacol (Pravastatin).
The researcher called this "probably chance" since the statin drugs are "so
safe" (?) a conclusion I find it difficult to understand - all the rat
trials showed a high incidence of cancer, so this increased incidence in the
trial seems a no brainer to me! A physician not a part of the research did
say that they should "watch" and see if this shows up again. (Obviously he
didn't quite buy the "chance" theory!) :)
Dr James Shephard - study reported at opening session of the American Heart
source: "Internal Medicine News" - Vol 36, no. 3, Feb 1, 2003 (newspaper for
NO DIFFERENCE in mortality rates from heart attacks
JAMA; Chicago; Dec 18, 2002; Curt D Furberg; Jackson T Wright Jr; Barry R
Davis; Jeffrey A Cutler; et al;
The Journal of the American Medical Association, Volume: 288, Issue: 23
Conclusions Pravastatin did not reduce either all-cause mortality or CHD
significantly when compared with usual care in older participants with
well-controlled hypertension and moderately elevated LDL-C. The results may
be due to the modest differential in total cholesterol (9.6%) and LDL-C
(16.7%) between pravastatin and usual care compared with prior statin trials
supporting cardiovascular disease prevention.
This study showed a slightly higher number of cancer deaths in the
Prevastatin patients (163) as compared to those not taking the drug.
Also, there was a higher incidence of those who came down with cancer in the
statin group (but did not die from it).
Got lung cancer?
One website owner felt he got lung cancer from Lipitor
and he also included a link to an AMA article showing for one thing that ALL
the Statins caused cancer in the rats, even in doses similar to what is
given to humans. The article writer pointed out that since there may be a
span of 20 years between starting the drug and the side effect of cancer,
it's hard to pinpoint it as a risk. However, the author believes the Statin
medication he took was a factor in his cancer. (His website is down - he may
succumbed to lung cancer.)
Statins and Myoglobin (article by an MIT research scientist - well
2. Stopped Our Statins website - a lot of research presented
Cancer.gov info website
4. Statin Induced cardiomyopathy
5. MS society studies on Zocor to suppress the
Lipitor warnings PDF