Drug-induced disorders

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Am Fam Physician. 1997 Nov 1;56(7):1781-8, 1791-2.

Drug-induced disorders.

Holland EG, Degruy FV.

University of South Alabama College of Medicine, Mobile, USA.

Comment in:

  • Am Fam Physician. 1997 Nov 1;56(7):1718, 1721.
  • Am Fam Physician. 1998 Jun;57(11):2615-6.
Recent estimates suggest that each year more than 1 million patients are injured while in the hospital and approximately 180,000 die because of these injuries. Furthermore, drug-related morbidity and mortality are common and are estimated to cost more than $136 billion a year. The most common type of drug-induced disorder is dose-dependent and predictable. Many adverse drug events occur as a result of drug-drug, drug-disease or drug-food interactions and, therefore, are preventable. Clinicians' awareness of the agents that commonly cause drug-induced disorders and recognition of compromised organ function can significantly decrease the likelihood that an adverse event will occur. Patient assessment should include a thorough medication history, including an analysis of all prescribed and over-the-counter medications, vitamins, herbs and "health-food" products to identify drug-induced problems and potentially reversible conditions. An increased awareness among clinicians of drug-induced disorders should maximize their recognition and minimize their incidence.

PMID: 9371009 [PubMed - indexed for MEDLINE]